In this presentation, Dr. Alex Artyomenko addresses the need to coordinate and collaborate across functions within both the Sponsor and CRO organizations to breed success when implementing a Risk Based Monitoring approach. Listeners will learn about taking holistic approach to building a customized adaptive monitoring program, its challenges, and perspectives for working with the medical, operational and technology teams. This topic was presented at the SCOPE Summit for Clinical Operations Executives in Orlando, FL, February 24-26, 2015.